Laboratory of Personalized Health (LPH): Delivering Personalized
Medicine in Real-time
The effectiveness of drugs and their potential for both benefit and side effects are not only the result of drug selection and dose but also the rate of drug metabolism and target interaction. For many drugs, this metabolism is accomplished by the Cytochrome P450 (CYP450) enzyme system located in the liver.
Variability in the CYP450 system, accumulated in humans since prehistoric times, results in strikingly different drug levels, drug effectiveness and drug safety among individuals when the recommended dose is designed to treat the "average" person. These variances, particularly relevant to drugs used in mental health, cardio-metabolic disease, and pain control, can now be measured by DNA typing before treatment. Drug doses can then be tailored to provide safe and effective therapy for individual patients (DNA-Guided Medicine).
The Laboratory for Personalized Health analyzes the CYP2C9, CYP2C19, and CYP2D6 genes simply from a blood sample or buccal swab from the patient. LPH then assists in the interpretation of these results for DNA-guided medical management of serious side effects and individualized optimization of therapy. The genotype results and guidance delivered by LPH markedly improve the safetly and efficacy of drug therapy by providing:
Personalized Health Portal (PHP): Medical Informatics Enabling DNA-Guided Medicine
The Personalized Health Portal integrates pharmacokinetic information available from the FDA, drug manufacturers, pharmacogenetic databases and studies by Genomas to determine the drugs that each patient would be most likely to tolerate and process given the person's innate drug metabolism capacity determined by the HILOmet PhyzioType System. PHP provides therapeutic guidance for 250 medications: 130 neuro-psychiatric drugs (antidepressants, neuroleptics, anticonvulsants, anxiolytics, stimulants, analgesics, hypnotics) and 120 cardio-metabolic drugs (to treat hypertension, diabetes, angina, thrombosis, GERD, ED, asthma). PHP is covered by U.S. Copyright Registration Number VA 1-797-692 (Personalized Health Portal).
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